ESPE Abstracts

Background: Decreased serum 25-hydroxyvitamin D (25-OHD) level has frequently been reported in obesity, a condition which is associated with insulin resistance. Insulin resistance was negatively associated with serum 25-OHD. Puberty is the period with altered insulin sensitivity. Previous studies showed conflicting results of the variation of serum 25-OHD levels across pubertal stages. However, data on serum 25-OHD levels across pubertal stages in obese childr...

Background: Subcutaneous gonadotropin-releasing hormone (GnRH) analog test is an alternative to standard intravenous GnRH test for diagnosing central precocious puberty (CPP). Previous studies showed different cutoffs of basal and peak serum LH levels following intravenous GnRH and subcutaneous GnRH analog for diagnosing CPP girls. However, no study that defined the discriminating basal and peak LH levels among CPP and premature thelarche (PT) girls with different breast Tanne...

Background: Elevated serum luteinizing hormone (LH) during gonadotropin-releasing hormone (GnRH) test is documented in girls with central precocious puberty (CPP). Lower LH secretion has been reported in obese girls as compared with lean girls. Few studies have addressed the effect of obesity on peak serum LH levels during GnRH test. This study aimed to determine peak serum LH levels during GnRH analog (GnRHa) test in CPP girls of different body mass index (BM...

Differences of sex development (DSD) are congenital conditions with discordance between chromosomal, gonadal and/or anatomic sex. DSD can be syndromic or non-syndromic based on the presence or absence of somatic anomalies, respectively. Variants in several genes have been identified in association with errors of testis determination and male genital differentiation. However, despite technological advances, a genetic diagnosis is not achieved in nearly 50% of individuals presen...